Version 5.4
Homo sapiens Gene: HOXA13
Summary
InnateDB Gene IDBG-10626.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXA13
Gene Name homeobox A13
Synonyms HOX1; HOX1J
Species Homo sapiens
Ensembl Gene ENSG00000106031
Encoded Proteins
IDBP-10628
homeobox A13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27193503-27200106
Strand Reverse strand
Band p15.2
Transcripts
ENST00000222753 ENSP00000222753
ENST00000518136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0001570 vasculogenesis
GO:0001886 endothelial cell morphogenesis
GO:0001894 tissue homeostasis
GO:0003281 ventricular septum development
GO:0006351 transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0030510 regulation of BMP signaling pathway
GO:0030539 male genitalia development
GO:0035115 embryonic forelimb morphogenesis
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048839 inner ear development
GO:0048844 artery morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060847 endothelial cell fate specification
GO:2001055 positive regulation of mesenchymal cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038203
View Gene Order
ENSBTAG00000014735
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592172 Hs.732907
RefSeq NM_000522
HUGO
OMIM
CCDS CCDS5412
HPRD 00847
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca