InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: C4BPB

Summary

InnateDB Gene

IDBG-106321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C4BPB

Gene Name

complement component 4 binding protein, beta

Synonyms

C4BP

Species

Homo sapiens

Ensembl Gene

ENSG00000123843

Encoded Proteins

IDBP-106323

complement component 4 binding protein, beta

IDBP-106325

complement component 4 binding protein, beta

IDBP-106327

complement component 4 binding protein, beta

IDBP-246706

complement component 4 binding protein, beta

IDBP-389975

complement component 4 binding protein, beta

IDBP-389976

complement component 4 binding protein, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21283780

C4BPB plays an inhibitory role in antimicrobial response by delaying the classical complement activation and attenuating the lectin pathway activation. The major inhibitory role of C4BPB is to facilitate the decay of C3 convertase.

Entrez Gene

Summary

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:207006845-207099993

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000367078	ENSP00000356045
ENST00000243611	ENSP00000243611
ENST00000367076	ENSP00000356043
ENST00000391923	ENSP00000375790
ENST00000452902	ENSP00000392237
ENST00000451804	ENSP00000405649
ENST00000492730
ENST00000469326
ENST00000470767

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006958	complement activation, classical pathway
GO:0007596	blood coagulation
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)
GO:0045732	positive regulation of protein catabolic process
GO:0045959	negative regulation of complement activation, classical pathway
GO:1903027	regulation of opsonization

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0044216	other organism cell

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_118707

Regulation of Complement cascade pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

REACT_6932

Complement cascade pathway

KEGG

hsa04610

Complement and coagulation cascades pathway

INOH

PID NCI

hnf3apathway

FOXA1 transcription factor network

Cross-References

SwissProt

P20851

TrEMBL

Q5VVQ7

UniProt Splice Variant

Entrez Gene

725

UniGene

RefSeq

NM_000716 NM_001017364 NM_001017365 NM_001017366 NM_001017367 XM_005273253 XM_005273254

HUGO

HGNC:1328

OMIM

120831

CCDS

CCDS1476 CCDS31005

HPRD

IMGT

EMBL

AL445493 BC005378 CH471100 EF613556 L11244 L11245 M29964

GenPept

AAA35615 AAA35616 AAB59520 AAH05378 ABQ52216 CAH70780 CAH70781 EAW93504 EAW93506

RNA Seq Atlas

725