Homo sapiens Gene: C4BPB | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-106321.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | C4BPB | ||||||||||||||||||
Gene Name | complement component 4 binding protein, beta | ||||||||||||||||||
Synonyms | C4BP | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000123843 | ||||||||||||||||||
Encoded Proteins |
complement component 4 binding protein, beta
complement component 4 binding protein, beta
complement component 4 binding protein, beta
complement component 4 binding protein, beta
complement component 4 binding protein, beta
complement component 4 binding protein, beta
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
C4BPB plays an inhibitory role in antimicrobial response by delaying the classical complement activation and attenuating the lectin pathway activation. The major inhibitory role of C4BPB is to facilitate the decay of C3 convertase.
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Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 1:207006845-207099993 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q32.1 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Regulation of Complement cascade pathway
Innate Immune System pathway
Immune System pathway
Complement cascade pathway
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KEGG |
Complement and coagulation cascades pathway
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INOH | |||||||||||||||||||
PID NCI |
FOXA1 transcription factor network
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Cross-References | |||||||||||||||||||
SwissProt | P20851 | ||||||||||||||||||
TrEMBL | Q5VVQ7 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 725 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_000716 NM_001017364 NM_001017365 NM_001017366 NM_001017367 XM_005273253 XM_005273254 | ||||||||||||||||||
HUGO | HGNC:1328 | ||||||||||||||||||
OMIM | 120831 | ||||||||||||||||||
CCDS | CCDS1476 CCDS31005 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AL445493 BC005378 CH471100 EF613556 L11244 L11245 M29964 | ||||||||||||||||||
GenPept | AAA35615 AAA35616 AAB59520 AAH05378 ABQ52216 CAH70780 CAH70781 EAW93504 EAW93506 | ||||||||||||||||||
RNA Seq Atlas | 725 | ||||||||||||||||||