Homo sapiens Gene: C4BPB
Summary
InnateDB Gene IDBG-106321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C4BPB
Gene Name complement component 4 binding protein, beta
Synonyms C4BP;
Species Homo sapiens
Ensembl Gene ENSG00000123843
Encoded Proteins
complement component 4 binding protein, beta
complement component 4 binding protein, beta
complement component 4 binding protein, beta
complement component 4 binding protein, beta
complement component 4 binding protein, beta
complement component 4 binding protein, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
C4BPB plays an inhibitory role in antimicrobial response by delaying the classical complement activation and attenuating the lectin pathway activation. The major inhibitory role of C4BPB is to facilitate the decay of C3 convertase.
Entrez Gene
Summary This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:207006845-207099993
Strand Forward strand
Band q32.1
Transcripts
ENST00000367078 ENSP00000356045
ENST00000243611 ENSP00000243611
ENST00000367076 ENSP00000356043
ENST00000391923 ENSP00000375790
ENST00000452902 ENSP00000392237
ENST00000451804 ENSP00000405649
ENST00000492730
ENST00000469326
ENST00000470767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006958 complement activation, classical pathway
GO:0007596 blood coagulation
GO:0030449 regulation of complement activation
GO:0045087 innate immune response (InnateDB)
GO:0045732 positive regulation of protein catabolic process
GO:0045959 negative regulation of complement activation, classical pathway
GO:1903027 regulation of opsonization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0044216 other organism cell
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
Regulation of Complement cascade pathway
Complement cascade pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
PID NCI
FOXA1 transcription factor network
Cross-References
SwissProt P20851
TrEMBL Q5VVQ7
UniProt Splice Variant
Entrez Gene 725
UniGene
RefSeq NM_001017365 NM_000716 NM_001017364 NM_001017366 NM_001017367 XM_005273253 XM_005273254
HUGO HGNC:1328
OMIM 120831
CCDS CCDS1476 CCDS31005
HPRD 00404
IMGT
EMBL AL445493 BC005378 CH471100 EF613556 L11244 L11245 M29964
GenPept AAA35615 AAA35616 AAB59520 AAH05378 ABQ52216 CAH70780 CAH70781 EAW93504 EAW93506
RNA Seq Atlas 725