Version 5.4
| Homo sapiens Gene: NSL1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-106575.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | NSL1 | ||||||||||||||||||
| Gene Name | NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) | ||||||||||||||||||
| Synonyms | C1orf48; MIS14 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000117697 | ||||||||||||||||||
| Encoded Proteins |
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3\' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:212726153-212791782 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q32.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Mitotic Metaphase and Anaphase pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | Q5SY76 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 25936 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001297739 NM_001297737 NM_015471 XM_006711267 | ||||||||||||||||||
| HUGO | HGNC:24548 | ||||||||||||||||||
| OMIM | 609174 | ||||||||||||||||||
| CCDS | CCDS1509 CCDS73025 | ||||||||||||||||||
| HPRD | 12378 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC104333 AL591647 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 25936 | ||||||||||||||||||