InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NSL1

Summary

InnateDB Protein

IDBP-106579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NSL1

Protein Name

NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)

Synonyms

C1orf48; MIS14;

Species

Homo sapiens

Ensembl Protein

ENSP00000355944

InnateDB Gene

IDBG-106575 (NSL1)

Protein Structure

UniProt Annotation

Function

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269PubMed:16585270}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.

Experimentally validated
Total	40 [view]
Protein-Protein	39 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division

Cellular Component

GO:0000444	MIS12/MIND type complex
GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR013950 Kinetochore Mis14

PFAM

PF08641

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96IY1

PhosphoSite

PhosphoSite-Q96IY1

TrEMBL

Q53FM2

UniProt Splice Variant

Entrez Gene

25936

UniGene

RefSeq

NP_056286

HUGO

HGNC:24548

OMIM

609174

CCDS

CCDS1509

HPRD

12378

IMGT

EMBL

AC104333 AF201941 AF255793 AK222996 AK223260 AL050084 AL591647 BC007067 CH471100

GenPept

AAF86877 AAG44640 AAH07067 BAD96716 BAD96980 CAB43260 CAI17046 EAW93379 EAW93380