Homo sapiens Gene: LEFTY2
Summary
InnateDB Gene IDBG-106991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEFTY2
Gene Name left-right determination factor 2
Synonyms EBAF; LEFTA; LEFTYA; TGFB4;
Species Homo sapiens
Ensembl Gene ENSG00000143768
Encoded Proteins
left-right determination factor 2
left-right determination factor 2
left-right determination factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:225936598-225941489
Strand Reverse strand
Band q42.12
Transcripts
ENST00000366820 ENSP00000355785
ENST00000420304 ENSP00000388009
ENST00000474493
ENST00000616737 ENSP00000484300
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0002576 platelet degranulation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007596 blood coagulation
GO:0016049 cell growth
GO:0030168 platelet activation
GO:0040007 growth
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Regulation of signaling by NODAL pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signaling by NODAL pathway
Hemostasis pathway
KEGG
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O00292
TrEMBL
UniProt Splice Variant
Entrez Gene 7044
UniGene Hs.520187 Hs.613871
RefSeq NM_001172425 NM_003240
HUGO HGNC:3122
OMIM 601877
CCDS CCDS53479 CCDS1549
HPRD 03526
IMGT
EMBL AF081508 AF081509 AF081510 AF081511 AF081513 AK027520 AK075344 AK304549 AL117348 BC035718 U81523
GenPept AAB53269 AAC32600 AAD48145 AAH35718 BAC11556 BAG51336 BAG65344 CAI21804
RNA Seq Atlas 7044