InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LEFTY2

Summary

InnateDB Protein

IDBP-106993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LEFTY2

Protein Name

left-right determination factor 2

Synonyms

EBAF; LEFTA; LEFTYA; TGFB4;

Species

Homo sapiens

Ensembl Protein

ENSP00000355785

InnateDB Gene

IDBG-106991 (LEFTY2)

Protein Structure

UniProt Annotation

Function

Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

Subcellular Localization

Secreted.

Disease Associations

Left-right axis malformations (LRAM) [MIM:601877]: The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. {ECO:0000269PubMed:10053005}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Mesenchymal cells of the endometrial stroma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005160	transforming growth factor beta receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0002576	platelet degranulation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0016049	cell growth
GO:0030168	platelet activation
GO:0040007	growth

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031093	platelet alpha granule lumen

Protein Structure and Domains

PDB ID

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR003942 Left- Right determination factor
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR01427

PIRSF

PIRSF037402

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References