Homo sapiens Gene: ADCK3
Summary
InnateDB Gene IDBG-107062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCK3
Gene Name aarF domain containing kinase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163050
Encoded Proteins
aarF domain containing kinase 3
aarF domain containing kinase 3
aarF domain containing kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:226897536-226987545
Strand Forward strand
Band q42.13
Transcripts
ENST00000366779 ENSP00000355741
ENST00000366778 ENSP00000355740
ENST00000366777 ENSP00000355739
ENST00000485677
ENST00000478406
ENST00000489044
ENST00000476488
ENST00000485462
ENST00000479852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006744 ubiquinone biosynthetic process
GO:0008219 cell death
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8NI60
TrEMBL Q5T7A2
UniProt Splice Variant
Entrez Gene 56997
UniGene Hs.118241
RefSeq NM_020247 XM_005273202 XM_005273201 XM_005273203
HUGO HGNC:16812
OMIM 606980
CCDS CCDS1557
HPRD 07375
IMGT
EMBL AB073905 AF218003 AJ278126 AK074693 AK090494 AL353689 BC005171 BX648860
GenPept AAG17245 AAH05171 BAB91363 BAC11143 BAG52171 CAC00482 CAH56132 CAI19103 CAI19105
RNA Seq Atlas 56997