InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCK3

Summary

InnateDB Protein

IDBP-107070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCK3

Protein Name

aarF domain containing kinase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355739

InnateDB Gene

IDBG-107062 (ADCK3)

Protein Structure

UniProt Annotation

Function

Putative protein kinase involved in the biosynthesis of coenzyme Q since it is able to rescue partially coenzyme Q6 biosynthesis of yeast COQ8 mutants. May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. {ECO:0000269PubMed:21296186}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:11888884}.

Disease Associations

Coenzyme Q10 deficiency, primary, 4 (COQ10D4) [MIM:612016]: An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. {ECO:0000269PubMed:18319072, ECO:0000269PubMed:18319074}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle. {ECO:0000269PubMed:24270420}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups