Version 5.4
Homo sapiens Gene: GUK1
Summary
InnateDB Gene IDBG-107175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GUK1
Gene Name guanylate kinase 1
Synonyms GMK
Species Homo sapiens
Ensembl Gene ENSG00000143774
Encoded Proteins
IDBP-107177
guanylate kinase 1
IDBP-107181
guanylate kinase 1
IDBP-107183
guanylate kinase 1
IDBP-107187
guanylate kinase 1
IDBP-107189
guanylate kinase 1
IDBP-107191
guanylate kinase 1
IDBP-107193
guanylate kinase 1
IDBP-107199
guanylate kinase 1
IDBP-107201
guanylate kinase 1
IDBP-246827
guanylate kinase 1
IDBP-390106
guanylate kinase 1
IDBP-390107
guanylate kinase 1
IDBP-390108
guanylate kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:228139962-228148984
Strand Forward strand
Band q42.13
Transcripts
ENST00000366730 ENSP00000355691
ENST00000366728 ENSP00000355689
ENST00000312726 ENSP00000317659
ENST00000366726 ENSP00000355687
ENST00000366723 ENSP00000355684
ENST00000366722 ENSP00000355683
ENST00000366721 ENSP00000355682
ENST00000366718 ENSP00000355679
ENST00000366716 ENSP00000355677
ENST00000391865 ENSP00000375738
ENST00000453943 ENSP00000401832
ENST00000435153 ENSP00000403664
ENST00000412265 ENSP00000407604
ENST00000462807
ENST00000493209
ENST00000485838
ENST00000469973
ENST00000485083
ENST00000492871
ENST00000493138
ENST00000498092
ENST00000485733
ENST00000491613
ENST00000460224
ENST00000484953
ENST00000472939
ENST00000470040
ENST00000485859
ENST00000478725
ENST00000485168
ENST00000495999
ENST00000486668
ENST00000464858
ENST00000481341
ENST00000498115
ENST00000465025
ENST00000477206
ENST00000471270
ENST00000480056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004385 guanylate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006163 purine nucleotide metabolic process
GO:0006185 dGDP biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0017144 drug metabolic process
GO:0019673 GDP-mannose metabolic process
GO:0034436 glycoprotein transport
GO:0044281 small molecule metabolic process
GO:0046034 ATP metabolic process
GO:0046037 GMP metabolic process
GO:0046054 dGMP metabolic process
GO:0046060 dATP metabolic process
GO:0046711 GDP biosynthetic process
GO:0046939 nucleotide phosphorylation
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020444
View Gene Order
ENSBTAG00000014775
Not yet available
Pathways
NETPATH
REACTOME
REACT_121388
Abacavir metabolism pathway
REACT_21330
Synthesis and interconversion of nucleotide di- and triphosphates pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_121189
Abacavir transport and metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.602494
RefSeq NM_000858 NM_001159390 NM_001159391 NM_001242839 NM_001242840 XM_005273103 XM_005273104 XM_005273105 XM_005273106
HUGO
OMIM
CCDS CCDS1568 CCDS53481 CCDS55689
HPRD 00755
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca