InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GUK1

Summary

InnateDB Protein

IDBP-107199.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUK1

Protein Name

guanylate kinase 1

Synonyms

GMK;

Species

Homo sapiens

Ensembl Protein

ENSP00000355679

InnateDB Gene

IDBG-107175 (GUK1)

Protein Structure

UniProt Annotation

Function

Essential for recycling GMP and indirectly, cGMP.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006163	purine nucleotide metabolic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0017144	drug metabolic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR017665 Guanylate kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00625

PRINTS

PIRSF

SMART

SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16774