Version 5.4
Homo sapiens Gene: JAM2
Summary
InnateDB Gene IDBG-1072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JAM2
Gene Name junctional adhesion molecule 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154721
Encoded Proteins
IDBP-1074
junctional adhesion molecule 2
IDBP-227998
junctional adhesion molecule 2
IDBP-480678
junctional adhesion molecule 2
IDBP-586152
junctional adhesion molecule 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:25639272-25717562
Strand Forward strand
Band q21.3
Transcripts
ENST00000312957 ENSP00000318416
ENST00000400532 ENSP00000383376
ENST00000480456 ENSP00000420419
ENST00000460679 ENSP00000436801
ENST00000492962
ENST00000477351
ENST00000471689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007162 negative regulation of cell adhesion
GO:0007596 blood coagulation
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005923 tight junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053062
View Gene Order
ENSBTAG00000000603
Not yet available
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 58494
UniGene Hs.517227 Hs.657514 Hs.657654
RefSeq NM_001270407 NM_001270408 NM_021219
HUGO HGNC:14686
OMIM 606870
CCDS CCDS42911 CCDS58787 CCDS58788
HPRD 06041
IMGT
EMBL
GenPept
RNA Seq Atlas 58494

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca