Version 5.4
Homo sapiens Gene: HIST3H3
Summary
InnateDB Gene IDBG-107261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST3H3
Gene Name histone cluster 3, H3
Synonyms H3.4; H3/g; H3FT; H3t
Species Homo sapiens
Ensembl Gene ENSG00000168148
Encoded Proteins
IDBP-107263
histone cluster 3, H3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:228424845-228425325
Strand Reverse strand
Band q42.13
Transcripts
ENST00000366696 ENSP00000355657
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
Experimentally validated
Total 207 [view]
Protein-Protein 193 [view]
Protein-DNA 13 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_16
IL4 pathway
NetPath_25
FSH pathway
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_7963
Packaging Of Telomere Ends pathway
REACT_27271
Meiotic recombination pathway
REACT_120956
Cellular responses to stress pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_11045
Signaling by Wnt pathway
REACT_22172
Chromosome Maintenance pathway
REACT_7970
Telomere Maintenance pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_111183
Meiosis pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt Q16695
TrEMBL
UniProt Splice Variant
Entrez Gene 8290
UniGene Hs.248171
RefSeq NM_003493
HUGO HGNC:4778
OMIM 602820
CCDS CCDS1572
HPRD
IMGT
EMBL AF531308 AK312217 AL139288 BC069079 BC101837 BC101839 CH471098 CR542013 Z49861
GenPept AAH69079 AAI01838 AAI01840 AAN39284 BAG35150 CAA90020 CAG46810 CAI23333 EAW69877
RNA Seq Atlas 8290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca