Version 5.4
Homo sapiens Protein: HIST3H3
Summary
InnateDB Protein IDBP-107263.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST3H3
Protein Name histone cluster 3, H3
Synonyms H3.4; H3/g; H3FT; H3t;
Species Homo sapiens
Ensembl Protein ENSP00000355657
InnateDB Gene IDBG-107261 (HIST3H3)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity Expressed in testicular cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
Experimentally validated
Total 207 [view]
Protein-Protein 193 [view]
Protein-DNA 13 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000164 Histone H3/CENP-A
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00622
PIRSF
SMART SM00428
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16695
PhosphoSite PhosphoSite-Q16695
TrEMBL
UniProt Splice Variant
Entrez Gene 8290
UniGene Hs.248171
RefSeq NP_003484
HUGO HGNC:4778
OMIM 602820
CCDS CCDS1572
HPRD 04156
IMGT
EMBL AF531308 AK312217 AL139288 BC069079 BC101837 BC101839 CH471098 CR542013 Z49861
GenPept AAH69079 AAI01838 AAI01840 AAN39284 BAG35150 CAA90020 CAG46810 CAI23333 EAW69877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca