Homo sapiens Gene: HIST3H2A
Summary
InnateDB Gene IDBG-107266.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST3H2A
Gene Name histone cluster 3, H2a
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000181218
Encoded Proteins
histone cluster 3, H2a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:228456979-228457873
Strand Reverse strand
Band q42.13
Transcripts
ENST00000366695 ENSP00000355656
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0006337 nucleosome disassembly
GO:0070914 UV-damage excision repair
Cellular Component
GO:0000786 nucleosome
GO:0000788 nuclear nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
KEGG
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q7L7L0
TrEMBL
UniProt Splice Variant
Entrez Gene 92815
UniGene Hs.26331 Hs.743797
RefSeq NM_033445
HUGO HGNC:20507
OMIM 615015
CCDS CCDS1573
HPRD 13660
IMGT
EMBL AK311930 AL139288 AY131974 BC082269 CH471098
GenPept AAN59960 BAG34871 CAI23331 EAW69878
RNA Seq Atlas 92815