Homo sapiens Gene: RHOU
Summary
InnateDB Gene IDBG-107287.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOU
Gene Name ras homolog family member U
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116574
Encoded Proteins
ras homolog gene family, member U
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:228735077-228746669
Strand Forward strand
Band q42.13
Transcripts
ENST00000366691 ENSP00000355652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008360 regulation of cell shape
GO:0015031 protein transport
GO:0016601 Rac protein signal transduction
GO:0030036 actin cytoskeleton organization
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0000139 Golgi membrane
GO:0002102 podosome
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Rho GTPases pathway
Signal Transduction pathway
Rho GTPase cycle pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595307 Hs.609878 Hs.647774
RefSeq NM_021205
HUGO
OMIM
CCDS CCDS1575
HPRD 06965
IMGT
EMBL
GenPept
RNA Seq Atlas