Version 5.4
Homo sapiens Gene: RHOU
Summary
InnateDB Gene IDBG-107287.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOU
Gene Name ras homolog family member U
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116574
Encoded Proteins
IDBP-107289
ras homolog gene family, member U
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:228735077-228746669
Strand Forward strand
Band q42.13
Transcripts
ENST00000366691 ENSP00000355652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008360 regulation of cell shape
GO:0015031 protein transport
GO:0016601 Rac protein signal transduction
GO:0030036 actin cytoskeleton organization
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0000139 Golgi membrane
GO:0002102 podosome
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039960
View Gene Order
ENSBTAG00000018691
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7L0Q8
TrEMBL A0A024R3Q7
UniProt Splice Variant
Entrez Gene 58480
UniGene Hs.595307 Hs.609878 Hs.647774
RefSeq NM_021205
HUGO HGNC:17794
OMIM 606366
CCDS CCDS1575
HPRD
IMGT
EMBL AB051826 AB074878 AB209511 AF211836 AF251701 AF282258 AF378087 AK289971 AL096776 BC040076 CH471098 DQ384420 DQ384421 DQ384422 DQ384423 DQ384424 DQ384425
GenPept AAG46058 AAH40076 AAK83340 AAL54874 AAL99390 ABD48870 ABD48871 ABD48872 ABD48873 ABD48874 ABD48875 BAB18638 BAB86361 BAD92748 BAF82660 CAC00584 EAW69885 EAW69886
RNA Seq Atlas 58480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca