Version 5.4
Homo sapiens Gene: TARBP1
Summary
InnateDB Gene IDBG-107510.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TARBP1
Gene Name TAR (HIV-1) RNA binding protein 1
Synonyms TRM3; TRP-185; TRP185
Species Homo sapiens
Ensembl Gene ENSG00000059588
Encoded Proteins
IDBP-107512
TAR (HIV-1) RNA binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:234391313-234479103
Strand Reverse strand
Band q42.2
Transcripts
ENST00000040877 ENSP00000040877
ENST00000483404
ENST00000462259
ENST00000496673
ENST00000471918
ENST00000484454
ENST00000468077
ENST00000481183
ENST00000463793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0008173 RNA methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006396 RNA processing
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000090290
View Gene Order
ENSBTAG00000004517
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.498115 Hs.609704
RefSeq NM_005646 XM_005273234 XM_006711812
HUGO
OMIM
CCDS CCDS1601
HPRD 05445
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca