Version 5.4
Homo sapiens Gene: NID1
Summary
InnateDB Gene IDBG-107579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NID1
Gene Name nidogen 1
Synonyms NID
Species Homo sapiens
Ensembl Gene ENSG00000116962
Encoded Proteins
IDBP-107581
nidogen 1
IDBP-107583
nidogen 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:235975830-236065162
Strand Reverse strand
Band q42.3
Transcripts
ENST00000264187 ENSP00000264187
ENST00000366595 ENSP00000355554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0043236 laminin binding
GO:0043237 laminin-1 binding
GO:0043394 proteoglycan binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0032836 glomerular basement membrane development
GO:0071711 basement membrane organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005397
View Gene Order
ENSBTAG00000007244
Not yet available
Pathways
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_169262
Laminin interactions pathway
KEGG
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
Cross-References
SwissProt P14543
TrEMBL
UniProt Splice Variant
Entrez Gene 4811
UniGene Hs.356624 Hs.598987 Hs.619437
RefSeq NM_002508
HUGO HGNC:7821
OMIM 131390
CCDS CCDS1608
HPRD
IMGT
EMBL AB209448 AL122018 AL139161 BC045606 M27445 M30269 X82245 X84819 X84820 X84821 X84822 X84823 X84824 X84825 X84826 X84827 X84828 X84829 X84830 X84831 X84832 X84833 X84834 X84835 X84836 X84837
GenPept AAA57261 AAA59932 AAH45606 BAD92685 CAA57709 CAI22680 CAI22681 CAI23421 CAI23422
RNA Seq Atlas 4811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca