Homo sapiens Gene: ADAM20
Summary
InnateDB Gene IDBG-10770.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM20
Gene Name ADAM metallopeptidase domain 20
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134007
Encoded Proteins
ADAM metallopeptidase domain 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70522358-70535015
Strand Reverse strand
Band q24.2
Transcripts
ENST00000256389 ENSP00000256389
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0032504 multicellular organism reproduction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Interaction With The Zona Pellucida pathway
Fertilization pathway
Reproduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O43506
TrEMBL
UniProt Splice Variant
Entrez Gene 8748
UniGene Hs.177984
RefSeq NM_003814 XM_005268151 XM_005268152
HUGO HGNC:199
OMIM 603712
CCDS CCDS32111
HPRD 04754
IMGT
EMBL AF029899 AF158643 AL357153 BC025378 CH471061
GenPept AAC52041 AAD55254 AAH25378 EAW81037
RNA Seq Atlas 8748