Homo sapiens Protein: ADAM20
Summary
InnateDB Protein IDBP-10772.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM20
Protein Name ADAM metallopeptidase domain 20
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000256389
InnateDB Gene IDBG-10770 (ADAM20)
Protein Structure
UniProt Annotation
Function May be involved in sperm maturation and/or fertilization.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Testis specific.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0032504 multicellular organism reproduction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
PFAM PF01421
PF00200
PF01562
PF08516
PRINTS PR00289
PIRSF
SMART SM00050
SM00608
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43506
PhosphoSite PhosphoSite-O43506
TrEMBL
UniProt Splice Variant
Entrez Gene 8748
UniGene Hs.177984
RefSeq NP_003805
HUGO HGNC:199
OMIM 603712
CCDS CCDS32111
HPRD 04754
IMGT
EMBL AF029899 AF158643 AL357153 BC025378 CH471061
GenPept AAC52041 AAD55254 AAH25378 EAW81037