Version 5.4
| Homo sapiens Gene: AKT3 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-107751.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | AKT3 | ||||||||||||||||||||||
| Gene Name | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | ||||||||||||||||||||||
| Synonyms | MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG; RAC-gamma; RAC-PK-gamma; STK-2 | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000117020 | ||||||||||||||||||||||
| Encoded Proteins |
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 1:243488233-243851079 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | q44 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
AKT phosphorylates targets in the nucleus pathway
Negative regulation of the PI3K/AKT network pathway
AKT phosphorylates targets in the cytosol pathway
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
CTLA4 inhibitory signaling pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
G beta:gamma signalling through PI3Kgamma pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
Downregulation of ERBB2:ERBB3 signaling pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Activation of BAD and translocation to mitochondria pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
AKT-mediated inactivation of FOXO1A pathway
Regulation of gene expression in beta cells pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Signaling by GPCR pathway
Innate Immune System pathway
Regulation of beta-cell development pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Intrinsic Pathway for Apoptosis pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
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| KEGG |
mTOR signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Apoptosis pathway
MAPK signaling pathway pathway
Melanoma pathway
Endometrial cancer pathway
Tight junction pathway
Glioma pathway
Small cell lung cancer pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Chronic myeloid leukemia pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Carbohydrate digestion and absorption pathway
Hepatitis C pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI |
Class I PI3K signaling events mediated by Akt
S1P3 pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Hs.498292 Hs.668762 Hs.668867 Hs.709089 Hs.734019 | ||||||||||||||||||||||
| RefSeq | NM_001206729 NM_005465 NM_181690 XM_005272994 XM_005272995 XM_005272997 XM_006711725 XM_006724959 XM_006724960 XM_006724961 XM_006724962 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS31076 CCDS31077 | ||||||||||||||||||||||
| HPRD | 06441 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||