Homo sapiens Gene: AKT3
Summary
InnateDB Gene IDBG-107751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKT3
Gene Name v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Synonyms MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG; RAC-gamma; RAC-PK-gamma; STK-2;
Species Homo sapiens
Ensembl Gene ENSG00000117020
Encoded Proteins
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:243488233-243851079
Strand Reverse strand
Band q44
Transcripts
ENST00000336199 ENSP00000336943
ENST00000366540 ENSP00000355498
ENST00000366539 ENSP00000355497
ENST00000263826 ENSP00000263826
ENST00000492957
ENST00000463991
ENST00000491219
ENST00000490018
ENST00000552631 ENSP00000447820
ENST00000550388
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
AKT-mediated inactivation of FOXO1A pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by GPCR pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Regulation of beta-cell development pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
Signaling by SCF-KIT pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
CD28 co-stimulation pathway
AKT phosphorylates targets in the cytosol pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
Regulation of gene expression in beta cells pathway
Downstream signal transduction pathway
GPVI-mediated activation cascade pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Intrinsic Pathway for Apoptosis pathway
Signaling by ERBB2 pathway
Costimulation by the CD28 family pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
CTLA4 inhibitory signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
AKT phosphorylates targets in the nucleus pathway
Negative regulation of the PI3K/AKT network pathway
Disease pathway
Activation of BAD and translocation to mitochondria pathway
Hemostasis pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Tight junction pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Class I PI3K signaling events mediated by Akt
S1P3 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.498292 Hs.668762 Hs.668867 Hs.709089 Hs.734019
RefSeq NM_001206729 NM_005465 NM_181690 XM_005272994 XM_005272995 XM_005272997 XM_006711725 XM_006724959 XM_006724960 XM_006724961 XM_006724962
HUGO
OMIM
CCDS CCDS31076 CCDS31077
HPRD 06441
IMGT
EMBL
GenPept
RNA Seq Atlas