Version 5.4
| Bos taurus Gene: AKT3 | |||||||||||||||||||||
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| Summary | |||||||||||||||||||||
| InnateDB Gene | IDBG-631371.3 | ||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
| Gene Symbol | AKT3 | ||||||||||||||||||||
| Gene Name | RAC-gamma serine/threonine-protein kinase | ||||||||||||||||||||
| Synonyms | |||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000017788 | ||||||||||||||||||||
| Encoded Proteins |
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
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| Protein Structure | |||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117020:
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||
| Genomic Location | Chromosome 16:34132648-34404652 | ||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||
| Band | |||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
Method
Confidence
Comments
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
| NETPATH | |||||||||||||||||||||
| REACTOME |
AKT-mediated inactivation of FOXO1A pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by GPCR pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Regulation of beta-cell development pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
Signaling by SCF-KIT pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
CD28 co-stimulation pathway
AKT phosphorylates targets in the cytosol pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
Regulation of gene expression in beta cells pathway
Downstream signal transduction pathway
GPVI-mediated activation cascade pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Intrinsic Pathway for Apoptosis pathway
Signaling by ERBB2 pathway
Costimulation by the CD28 family pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
CTLA4 inhibitory signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
AKT phosphorylates targets in the nucleus pathway
Negative regulation of the PI3K/AKT network pathway
Disease pathway
Activation of BAD and translocation to mitochondria pathway
Hemostasis pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
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| KEGG |
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Tight junction pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Tight junction pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
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| INOH |
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
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| PID BIOCARTA | |||||||||||||||||||||
| PID NCI |
Class I PI3K signaling events mediated by Akt
S1P3 pathway
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| Cross-References | |||||||||||||||||||||
| SwissProt | |||||||||||||||||||||
| TrEMBL | F1MYJ4 | ||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||
| Entrez Gene | 100137872 | ||||||||||||||||||||
| UniGene | Bt.40698 | ||||||||||||||||||||
| RefSeq | NM_001191309 XM_005216793 | ||||||||||||||||||||
| HUGO | HGNC:393 | ||||||||||||||||||||
| OMIM | |||||||||||||||||||||
| CCDS | |||||||||||||||||||||
| HPRD | |||||||||||||||||||||
| IMGT | |||||||||||||||||||||
| EMBL | DAAA02042758 DAAA02042759 DAAA02042760 DAAA02042761 DAAA02042762 DAAA02042763 | ||||||||||||||||||||
| GenPept | |||||||||||||||||||||
| RNA Seq Atlas | 100137872 | ||||||||||||||||||||
| Transcript Frequencies | |||||||||||||||||||||
| Tag Count based mRNA-Abundances across 87 different Tissues (TPM).
Based on Data from Bovine Gene Atlas |
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