Version 5.4
Homo sapiens Gene: BIN3
Summary
InnateDB Gene IDBG-11206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BIN3
Gene Name bridging integrator 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147439
Encoded Proteins
IDBP-11208
bridging integrator 3
IDBP-229321
bridging integrator 3
IDBP-481811
bridging integrator 3
IDBP-476340
bridging integrator 3
IDBP-479119
bridging integrator 3
IDBP-480946
bridging integrator 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22620418-22669148
Strand Reverse strand
Band p21.3
Transcripts
ENST00000276416 ENSP00000276416
ENST00000399977 ENSP00000382859
ENST00000520489
ENST00000519513 ENSP00000430423
ENST00000519335
ENST00000519863
ENST00000522687 ENSP00000430546
ENST00000520292 ENSP00000429660
ENST00000521140
ENST00000518366
ENST00000522268 ENSP00000428768
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity
Biological Process
GO:0000910 cytokinesis
GO:0000917 barrier septum assembly
GO:0007015 actin filament organization
GO:0008104 protein localization
GO:0009826 unidimensional cell growth
GO:0010591 regulation of lamellipodium assembly
GO:0014839 myoblast migration involved in skeletal muscle regeneration
GO:0043403 skeletal muscle tissue regeneration
GO:0048741 skeletal muscle fiber development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005884 actin filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022089
View Gene Order
ENSBTAG00000005470
Not yet available
Cross-References
SwissProt Q9NQY0
TrEMBL E5RGB5 E5RHU4 E5RJI6 H7BYV6
UniProt Splice Variant
Entrez Gene 55909
UniGene Hs.654720
RefSeq NM_018688 XM_005273573
HUGO HGNC:1054
OMIM 606396
CCDS CCDS47825
HPRD
IMGT
EMBL AC037459 AC105046 AF271732 AK001289 AK023980 BC001223 BC009824
GenPept AAF76218 AAH01223 AAH09824 BAA91603 BAB14751
RNA Seq Atlas 55909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca