Version 5.4
Homo sapiens Gene: TNFRSF10B
Summary
InnateDB Gene IDBG-11376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF10B
Gene Name tumor necrosis factor receptor superfamily, member 10b
Synonyms CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
Species Homo sapiens
Ensembl Gene ENSG00000120889
Encoded Proteins
IDBP-11378
tumor necrosis factor receptor superfamily, member 10b
IDBP-11382
tumor necrosis factor receptor superfamily, member 10b
IDBP-480339
tumor necrosis factor receptor superfamily, member 10b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:23020133-23069179
Strand Reverse strand
Band p21.3
Transcripts
ENST00000276431 ENSP00000276431
ENST00000347739 ENSP00000317859
ENST00000523752
ENST00000523504 ENSP00000427999
ENST00000520109
ENST00000518531
ENST00000519910
ENST00000519028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
Experimentally validated
Total 53 [view]
Protein-Protein 44 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0045569 TRAIL binding
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0034976 response to endoplasmic reticulum stress
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071260 cellular response to mechanical stimulus
GO:0097190 apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_832
Dimerization of procaspase-8 pathway
REACT_1503
Caspase-8 activation by cleavage pathway
REACT_402
TRAIL signaling pathway
REACT_1059
Extrinsic Pathway for Apoptosis pathway
REACT_578
Apoptosis pathway
REACT_164011
Regulation by c-FLIP pathway
REACT_1619
Death Receptor Signalling pathway
KEGG
hsa04210
Apoptosis pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
trail_pathway
TRAIL signaling pathway
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt O14763
TrEMBL B7Z3M7 B7Z588 E9PBT3 Q9BY82
UniProt Splice Variant
Entrez Gene 8795
UniGene Hs.521456 Hs.619052 Hs.635647
RefSeq NM_003842 NM_147187
HUGO HGNC:11905
OMIM 603612
CCDS CCDS6035 CCDS6036
HPRD
IMGT
EMBL AB014718 AB054004 AC107959 AF012535 AF012628 AF016266 AF016268 AF016849 AF018657 AF018658 AF020501 AF022386 AF153687 AF192548 AK296128 AK298602 AY358277 BC001281 BX538104
GenPept AAB67103 AAB67109 AAB70577 AAB70578 AAB71412 AAB71949 AAB81180 AAC01565 AAC51778 AAF07175 AAF75587 AAH01281 AAQ88644 BAA33723 BAB39708 BAH12263 BAH12824 CAD98017
RNA Seq Atlas 8795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca