InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNFRSF10B

Summary

InnateDB Gene

IDBG-11376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF10B

Gene Name

tumor necrosis factor receptor superfamily, member 10b

Synonyms

CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9;

Species

Homo sapiens

Ensembl Gene

ENSG00000120889

Encoded Proteins

IDBP-11378

tumor necrosis factor receptor superfamily, member 10b

IDBP-11382

tumor necrosis factor receptor superfamily, member 10b

IDBP-480339

tumor necrosis factor receptor superfamily, member 10b

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:23020133-23069179

Strand

Reverse strand

Band

p21.3

Transcripts

ENST00000276431	ENSP00000276431
ENST00000347739	ENSP00000317859
ENST00000523752
ENST00000523504	ENSP00000427999
ENST00000520109
ENST00000518531
ENST00000519910
ENST00000519028

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	44 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0045569	TRAIL binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0034976	response to endoplasmic reticulum stress
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071260	cellular response to mechanical stimulus
GO:0097190	apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand