InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF10B

Summary

InnateDB Protein

IDBP-11382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF10B

Protein Name

tumor necrosis factor receptor superfamily, member 10b

Synonyms

CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9;

Species

Homo sapiens

Ensembl Protein

ENSP00000317859

InnateDB Gene

IDBG-11376 (TNFRSF10B)

Protein Structure

UniProt Annotation

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269PubMed:15322075}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	44 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0045569	TRAIL binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0034976	response to endoplasmic reticulum stress
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071260	cellular response to mechanical stimulus
GO:0097190	apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand