Version 5.4
Homo sapiens Gene: IRX1
Summary
InnateDB Gene IDBG-11426.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRX1
Gene Name iroquois homeobox 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170549
Encoded Proteins
IDBP-11428
iroquois homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:3596054-3601403
Strand Forward strand
Band p15.33
Transcripts
ENST00000302006 ENSP00000305244
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001656 metanephros development
GO:0006355 regulation of transcription, DNA-templated
GO:0072086 specification of loop of Henle identity
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060969
View Gene Order
ENSBTAG00000000809
Not yet available
Cross-References
SwissProt P78414
TrEMBL
UniProt Splice Variant
Entrez Gene 79192
UniGene Hs.424156
RefSeq NM_024337
HUGO HGNC:14358
OMIM 606197
CCDS CCDS34132
HPRD
IMGT
EMBL AY335938 AY335947 BC029160 U90307
GenPept AAB50005 AAH29160 AAQ16544 AAQ16553
RNA Seq Atlas 79192

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca