Homo sapiens Gene: IL32
Summary
InnateDB Gene IDBG-11512.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL32
Gene Name interleukin 32
Synonyms IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd;
Species Homo sapiens
Ensembl Gene ENSG00000008517
Encoded Proteins
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
interleukin 32
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL32 enhances host immunity to Mycobacterium tuberculosis.
Entrez Gene
Summary This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3065297-3082192
Strand Forward strand
Band p13.3
Transcripts
ENST00000325568 ENSP00000324742
ENST00000382213 ENSP00000371648
ENST00000008180 ENSP00000008180
ENST00000396890 ENSP00000380099
ENST00000396887 ENSP00000380096
ENST00000440815 ENSP00000405063
ENST00000444393 ENSP00000411958
ENST00000534507 ENSP00000431775
ENST00000531965 ENSP00000433177
ENST00000532086
ENST00000529699 ENSP00000436937
ENST00000526464 ENSP00000450364
ENST00000529550 ENSP00000437020
ENST00000551122 ENSP00000447496
ENST00000525643 ENSP00000432218
ENST00000548807 ENSP00000448354
ENST00000528163 ENSP00000432850
ENST00000530890 ENSP00000433747
ENST00000533097 ENSP00000432917
ENST00000534748
ENST00000532247
ENST00000525228 ENSP00000431740
ENST00000548652 ENSP00000446624
ENST00000525377 ENSP00000433866
ENST00000530538 ENSP00000436929
ENST00000549213 ENSP00000447812
ENST00000552936 ENSP00000447033
ENST00000548476 ENSP00000449483
ENST00000552664 ENSP00000448683
ENST00000552356 ENSP00000446978
ENST00000551513 ENSP00000449147
ENST00000548246 ENSP00000447979
ENST00000528652
ENST00000525003
ENST00000613483 ENSP00000479701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P24001
TrEMBL C6GKH2
UniProt Splice Variant
Entrez Gene 9235
UniGene
RefSeq NM_001012718 NM_004221 NM_001012633 NM_001012631 NM_001012635 NM_001012634 NM_001012632 NM_001012636 XM_005255686
HUGO HGNC:16830
OMIM 606001
CCDS CCDS32377 CCDS32378 CCDS45394 CCDS32379
HPRD 09346
IMGT
EMBL AC108134 AK296143 AY495331 AY495332 AY495333 AY495334 BC009401 BC018782 BC105602 BM825040 CH471112 EU339107 FJ985781 M59807
GenPept AAA36367 AAH09401 AAH18782 AAI05603 AAS80143 AAS80144 AAS80145 AAS80146 AAS80147 AAS80148 ACA50721 ACS74770 BAG58883 EAW85405 EAW85406 EAW85407 EAW85408 EAW85409 EAW85410
RNA Seq Atlas 9235