Version 5.4
Homo sapiens Protein: IL32
Summary
InnateDB Protein IDBP-598465.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL32
Protein Name interleukin 32
Synonyms IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd;
Species Homo sapiens
Ensembl Protein ENSP00000448683
InnateDB Gene IDBG-11512 (IL32)
Protein Structure
UniProt Annotation
Function Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF- alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. {ECO:0000269PubMed:15664165}.
Subcellular Localization Secreted {ECO:0000269PubMed:15664165}.
Disease Associations
Tissue Specificity Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells. {ECO:0000269PubMed:15664165}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0006955 immune response
GO:0007155 cell adhesion
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P24001
PhosphoSite PhosphoSite-P24001
TrEMBL C6GKH2
UniProt Splice Variant
Entrez Gene 9235
UniGene
RefSeq NP_001012650
HUGO HGNC:16830
OMIM 606001
CCDS CCDS32377
HPRD 09346
IMGT
EMBL AC108134 AK296143 AY495331 AY495332 AY495333 AY495334 BC009401 BC018782 BC105602 BM825040 CH471112 EU339107 FJ985781 M59807
GenPept AAA36367 AAH09401 AAH18782 AAI05603 AAS80143 AAS80144 AAS80145 AAS80146 AAS80147 AAS80148 ACA50721 ACS74770 BAG58883 EAW85405 EAW85406 EAW85407 EAW85408 EAW85409 EAW85410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca