Version 5.4
Homo sapiens Gene: SRD5A1
Summary
InnateDB Gene IDBG-11624.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRD5A1
Gene Name steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Synonyms S5AR 1
Species Homo sapiens
Ensembl Gene ENSG00000145545
Encoded Proteins
IDBP-11626
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
IDBP-484954
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
IDBP-485221
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:6633343-6669562
Strand Forward strand
Band p15.31
Transcripts
ENST00000274192 ENSP00000274192
ENST00000510531 ENSP00000425330
ENST00000513117 ENSP00000421342
ENST00000504286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0047751 cholestenone 5-alpha-reductase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006702 androgen biosynthetic process
GO:0007530 sex determination
GO:0007548 sex differentiation
GO:0008202 steroid metabolic process
GO:0030154 cell differentiation
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021594
View Gene Order
ENSBTAG00000015478
Not yet available
Pathways
NETPATH
REACTOME
REACT_11059
Androgen biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RG03
UniProt Splice Variant
Entrez Gene 6715
UniGene Hs.552 Hs.618502
RefSeq NM_001047
HUGO HGNC:11284
OMIM 184753
CCDS CCDS3870
HPRD 01699
IMGT
EMBL AC010366
GenPept
RNA Seq Atlas 6715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca