InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRD5A1

Summary

InnateDB Protein

IDBP-11626.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRD5A1

Protein Name

steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Synonyms

S5AR 1;

Species

Homo sapiens

Ensembl Protein

ENSP00000274192

InnateDB Gene

IDBG-11624 (SRD5A1)

Protein Structure

UniProt Annotation

Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Subcellular Localization

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Liver and prostate (at a low level).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0047751	cholestenone 5-alpha-reductase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006702	androgen biosynthetic process
GO:0007530	sex determination
GO:0007548	sex differentiation
GO:0008202	steroid metabolic process
GO:0030154	cell differentiation
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
IPR010721 Protein of unknown function DUF1295
IPR016636 3-oxo-5-alpha-steroid 4-dehydrogenase

PFAM

PF02544
PF06966

PRINTS

PIRSF

PIRSF015596

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P18405