Version 5.4
Homo sapiens Gene: GPR125
Summary
InnateDB Gene IDBG-11637.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR125
Gene Name G protein-coupled receptor 125
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152990
Encoded Proteins
IDBP-11639
G protein-coupled receptor 125
IDBP-485103
G protein-coupled receptor 125
IDBP-481207
G protein-coupled receptor 125
IDBP-476390
G protein-coupled receptor 125
IDBP-480796
G protein-coupled receptor 125
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:22345071-22516054
Strand Reverse strand
Band p15.2
Transcripts
ENST00000334304 ENSP00000334952
ENST00000282943
ENST00000511051 ENSP00000424927
ENST00000499527
ENST00000504617
ENST00000506155
ENST00000508133 ENSP00000422606
ENST00000502482 ENSP00000421006
ENST00000514129 ENSP00000425223
ENST00000506133
ENST00000513385
ENST00000514749
ENST00000506346
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029090
View Gene Order
ENSBTAG00000004653
Not yet available
Cross-References
SwissProt Q8IWK6
TrEMBL D6RDX4
UniProt Splice Variant
Entrez Gene 166647
UniGene Hs.737680 Hs.99195
RefSeq NM_145290
HUGO HGNC:13839
OMIM 612303
CCDS CCDS33964
HPRD 11011
IMGT
EMBL AC093735 AC093814 AY181243 AY358306 BC026009 BC035645
GenPept AAH35645 AAO27355 AAQ88673
RNA Seq Atlas 166647

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca