Homo sapiens Gene: GPR125
Summary
InnateDB Gene IDBG-11637.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR125
Gene Name G protein-coupled receptor 125
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152990
Encoded Proteins
G protein-coupled receptor 125
G protein-coupled receptor 125
G protein-coupled receptor 125
G protein-coupled receptor 125
G protein-coupled receptor 125
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:22345071-22516054
Strand Reverse strand
Band p15.2
Transcripts
ENST00000334304 ENSP00000334952
ENST00000282943
ENST00000511051 ENSP00000424927
ENST00000499527
ENST00000504617
ENST00000506155
ENST00000508133 ENSP00000422606
ENST00000502482 ENSP00000421006
ENST00000514129 ENSP00000425223
ENST00000506133
ENST00000513385
ENST00000514749
ENST00000506346
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.737680 Hs.99195
RefSeq NM_145290
HUGO
OMIM
CCDS CCDS33964
HPRD 11011
IMGT
EMBL
GenPept
RNA Seq Atlas