Homo sapiens Gene: TNFRSF10A
Summary
InnateDB Gene IDBG-11715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF10A
Gene Name tumor necrosis factor receptor superfamily, member 10a
Synonyms APO2; CD261; DR4; TRAILR-1; TRAILR1;
Species Homo sapiens
Ensembl Gene ENSG00000104689
Encoded Proteins
tumor necrosis factor receptor superfamily, member 10a
tumor necrosis factor receptor superfamily, member 10a
tumor necrosis factor receptor superfamily, member 10a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:23190452-23225126
Strand Reverse strand
Band p21.3
Transcripts
ENST00000221132 ENSP00000221132
ENST00000519862
ENST00000524158 ENSP00000428884
ENST00000613472 ENSP00000480778
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004872 receptor activity
GO:0005035 death receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0045569 TRAIL binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
KitReceptor pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Natural killer cell mediated cytotoxicity pathway
INOH
PID BIOCARTA
Induction of apoptosis through dr3 and dr4/5 death receptors [Biocarta view]
PID NCI
Caspase Cascade in Apoptosis
TRAIL signaling pathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL E5RFH1 F8U8C0
UniProt Splice Variant
Entrez Gene 8797
UniGene
RefSeq NM_003844
HUGO HGNC:11904
OMIM 603611
CCDS CCDS6039
HPRD
IMGT
EMBL AC100861 JF729355
GenPept AEB77762
RNA Seq Atlas 8797