Version 5.4
Homo sapiens Gene: TNFRSF10A
Summary
InnateDB Gene IDBG-11715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF10A
Gene Name tumor necrosis factor receptor superfamily, member 10a
Synonyms APO2; CD261; DR4; TRAILR-1; TRAILR1
Species Homo sapiens
Ensembl Gene ENSG00000104689
Encoded Proteins
IDBP-11719
tumor necrosis factor receptor superfamily, member 10a
IDBP-477571
tumor necrosis factor receptor superfamily, member 10a
IDBP-811394
tumor necrosis factor receptor superfamily, member 10a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:23190452-23225126
Strand Reverse strand
Band p21.3
Transcripts
ENST00000221132 ENSP00000221132
ENST00000519862
ENST00000524158 ENSP00000428884
ENST00000613472 ENSP00000480778
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004872 receptor activity
GO:0005035 death receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0045569 TRAIL binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
hsa04210
Apoptosis pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
trail_pathway
TRAIL signaling pathway
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.401745 Hs.591834
RefSeq NM_003844
HUGO
OMIM
CCDS CCDS6039
HPRD 04679
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca