InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF10A

Summary

InnateDB Protein

IDBP-11719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF10A

Protein Name

tumor necrosis factor receptor superfamily, member 10a

Synonyms

APO2; CD261; DR4; TRAILR-1; TRAILR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000221132

InnateDB Gene

IDBG-11715 (TNFRSF10A)

Protein Structure

UniProt Annotation

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. {ECO:0000269PubMed:9430227}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004872	receptor activity
GO:0005035	death receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0045569	TRAIL binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0036462	TRAIL-activated apoptotic signaling pathway
GO:0071260	cellular response to mechanical stimulus
GO:0097191	extrinsic apoptotic signaling pathway