InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHRM4

Summary

InnateDB Gene

IDBG-119194.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRM4

Gene Name

cholinergic receptor, muscarinic 4

Synonyms

HM4; M4R

Species

Homo sapiens

Ensembl Gene

ENSG00000180720

Encoded Proteins

IDBP-372439

cholinergic receptor, muscarinic 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:46385098-46386608

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000433765

ENSP00000409378

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016907	G-protein coupled acetylcholine receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0008283	cell proliferation
GO:0040012	regulation of locomotion

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000040495

View Gene Order

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_16943

Muscarinic acetylcholine receptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P08173

TrEMBL

UniProt Splice Variant

Entrez Gene

1132

UniGene

Hs.248100

RefSeq

NM_000741

HUGO

HGNC:1953

OMIM

118495

CCDS

CCDS44581

HPRD

00330

IMGT

EMBL

AF498918 BC095546 BC119775 BC119817 BC137535 CH471064 M16405 X15265

GenPept

AAA51571 AAH95546 AAI19776 AAI19818 AAI37536 AAM18941 CAA33336 EAW68004

RNA Seq Atlas

1132