Homo sapiens Gene: CHRM4
Summary
InnateDB Gene IDBG-119194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRM4
Gene Name cholinergic receptor, muscarinic 4
Synonyms HM4; M4R;
Species Homo sapiens
Ensembl Gene ENSG00000180720
Encoded Proteins
cholinergic receptor, muscarinic 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:46385098-46386608
Strand Reverse strand
Band p11.2
Transcripts
ENST00000433765 ENSP00000409378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0016907 G-protein coupled acetylcholine receptor activity
Biological Process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0008283 cell proliferation
GO:0040012 regulation of locomotion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Muscarinic acetylcholine receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P08173
TrEMBL
UniProt Splice Variant
Entrez Gene 1132
UniGene Hs.248100
RefSeq NM_000741
HUGO HGNC:1953
OMIM 118495
CCDS CCDS44581
HPRD 00330
IMGT
EMBL AF498918 BC095546 BC119775 BC119817 BC137535 CH471064 M16405 X15265
GenPept AAA51571 AAH95546 AAI19776 AAI19818 AAI37536 AAM18941 CAA33336 EAW68004
RNA Seq Atlas 1132