Mus musculus Gene: Chrm4
Summary
InnateDB Gene IDBG-191763.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chrm4
Gene Name cholinergic receptor, muscarinic 4
Synonyms Chrm-4; M4;
Species Mus musculus
Ensembl Gene ENSMUSG00000040495
Encoded Proteins
cholinergic receptor, muscarinic 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180720:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91927249-91928688
Strand Forward strand
Band E1
Transcripts
ENSMUST00000045537 ENSMUSP00000040808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0016907 G-protein coupled acetylcholine receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
GO:0040012 regulation of locomotion
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Amine ligand-binding receptors pathway
Muscarinic acetylcholine receptors pathway
GPCR ligand binding pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Muscarinic acetylcholine receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P32211
TrEMBL Q0VBU3
UniProt Splice Variant
Entrez Gene 12672
UniGene Mm.330405
RefSeq NM_007699 XM_006498654
OMIM
CCDS CCDS16439
HPRD
IMGT
MGI ID MGI:88399
MGI Symbol Chrm4
EMBL BC120504 BC137677 CH466519 S74916 X63473
GenPept AAB33577 AAI20505 AAI37678 CAA45071 EDL27579
RNA Seq Atlas 12672