Homo sapiens Gene: CYP19A1
Summary
InnateDB Gene IDBG-11985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP19A1
Gene Name cytochrome P450, family 19, subfamily A, polypeptide 1
Synonyms ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM;
Species Homo sapiens
Ensembl Gene ENSG00000137869
Encoded Proteins
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:51208057-51338610
Strand Reverse strand
Band q21.2
Transcripts
ENST00000260433 ENSP00000260433
ENST00000396404 ENSP00000379685
ENST00000396402 ENSP00000379683
ENST00000405913 ENSP00000383930
ENST00000405011 ENSP00000384389
ENST00000439712 ENSP00000390614
ENST00000453807 ENSP00000391139
ENST00000490076
ENST00000478421
ENST00000492852
ENST00000559878 ENSP00000453149
ENST00000559653 ENSP00000452667
ENST00000557934 ENSP00000454004
ENST00000558066
ENST00000561075 ENSP00000454039
ENST00000558328 ENSP00000453280
ENST00000557858 ENSP00000452627
ENST00000559980 ENSP00000452872
ENST00000559646 ENSP00000453318
ENST00000561066
ENST00000613097 ENSP00000479587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0009055 electron carrier activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0008209 androgen metabolic process
GO:0016125 sterol metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0060736 prostate gland growth
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Estrogen biosynthesis pathway
Metabolism of steroid hormones and vitamin D pathway
Cytochrome P450 - arranged by substrate type pathway
Endogenous sterols pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Steroid hormone biosynthesis pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.260074 Hs.669832
RefSeq NM_000103 NM_031226 XM_005254190 XM_005254191
HUGO
OMIM
CCDS CCDS10139
HPRD 00488
IMGT
EMBL
GenPept
RNA Seq Atlas