Homo sapiens Gene: CYP19A1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-11985.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CYP19A1 | ||||||||||||||||||
Gene Name | cytochrome P450, family 19, subfamily A, polypeptide 1 | ||||||||||||||||||
Synonyms | ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000137869 | ||||||||||||||||||
Encoded Proteins |
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
cytochrome P450, family 19, subfamily A, polypeptide 1
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 15:51208057-51338610 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q21.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Estrogen biosynthesis pathway
Endogenous sterols pathway
Metabolism of lipids and lipoproteins pathway
Metabolism of steroid hormones and vitamin D pathway
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
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KEGG |
Steroid hormone biosynthesis pathway
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INOH |
Tryptophan degradation pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | E9PGZ6 H0YKN1 H0YLS2 Q16449 Q8IYJ7 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 1588 | ||||||||||||||||||
UniGene | Hs.260074 Hs.669832 | ||||||||||||||||||
RefSeq | NM_000103 NM_031226 XM_005254190 XM_005254191 | ||||||||||||||||||
HUGO | HGNC:2594 | ||||||||||||||||||
OMIM | 107910 | ||||||||||||||||||
CCDS | CCDS10139 | ||||||||||||||||||
HPRD | 00488 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC012169 AC020891 BC035714 S85356 | ||||||||||||||||||
GenPept | AAB21520 AAH35714 | ||||||||||||||||||
RNA Seq Atlas | 1588 | ||||||||||||||||||