Version 5.4
Homo sapiens Gene: PPAP2C
Summary
InnateDB Gene IDBG-12008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAP2C
Gene Name phosphatidic acid phosphatase type 2C
Synonyms LPP2; PAP-2c; PAP2-g
Species Homo sapiens
Ensembl Gene ENSG00000141934
Encoded Proteins
IDBP-12010
phosphatidic acid phosphatase type 2C
IDBP-12012
phosphatidic acid phosphatase type 2C
IDBP-361178
phosphatidic acid phosphatase type 2C
IDBP-760815
IDBP-765071
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:281040-291504
Strand Reverse strand
Band p13.3
Transcripts
ENST00000269812 ENSP00000269812
ENST00000327790 ENSP00000329697
ENST00000434325 ENSP00000388565
ENST00000586998 ENSP00000466947
ENST00000591572 ENSP00000466545
ENST00000589672
ENST00000621795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0008195 phosphatidate phosphatase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0016311 dephosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052151
View Gene Order
ENSBTAG00000000717
Not yet available
Pathways
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa00561
Glycerolipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8612
UniGene
RefSeq NM_003712 NM_177526 NM_177543
HUGO HGNC:9230
OMIM 607126
CCDS CCDS12023 CCDS12024 CCDS45889
HPRD 06180
IMGT
EMBL
GenPept
RNA Seq Atlas 8612

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca