Homo sapiens Gene: PPAP2C
Summary
InnateDB Gene IDBG-12008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAP2C
Gene Name phosphatidic acid phosphatase type 2C
Synonyms LPP2; PAP-2c; PAP2-g;
Species Homo sapiens
Ensembl Gene ENSG00000141934
Encoded Proteins
phosphatidic acid phosphatase type 2C
phosphatidic acid phosphatase type 2C
phosphatidic acid phosphatase type 2C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:281040-291504
Strand Reverse strand
Band p13.3
Transcripts
ENST00000269812 ENSP00000269812
ENST00000327790 ENSP00000329697
ENST00000434325 ENSP00000388565
ENST00000586998 ENSP00000466947
ENST00000591572 ENSP00000466545
ENST00000589672
ENST00000621795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0008195 phosphatidate phosphatase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0016311 dephosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Sphingolipid de novo biosynthesis pathway
Metabolism pathway
KEGG
Glycerolipid metabolism pathway
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Sphingolipid metabolism pathway
Fc gamma R-mediated phagocytosis pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003712 NM_177526 NM_177543
HUGO
OMIM
CCDS CCDS12023 CCDS12024 CCDS45889
HPRD 06180
IMGT
EMBL
GenPept
RNA Seq Atlas