InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPAP2C

Summary

InnateDB Protein

IDBP-12012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPAP2C

Protein Name

phosphatidic acid phosphatase type 2C

Synonyms

LPP2; PAP-2c; PAP2-g;

Species

Homo sapiens

Ensembl Protein

ENSP00000329697

InnateDB Gene

IDBG-12008 (PPAP2C)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Found mainly in brain, pancreas and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0008195	phosphatidate phosphatase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0016311	dephosphorylation
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process