Version 5.4
Homo sapiens Gene: TRMU
Summary
InnateDB Gene IDBG-12047.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRMU
Gene Name tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100416
Encoded Proteins
IDBP-12049
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
IDBP-12051
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
IDBP-12053
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
IDBP-380235
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
IDBP-380237
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
IDBP-380238
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
IDBP-380239
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:46330875-46357340
Strand Forward strand
Band q13.31
Transcripts
ENST00000381021 ENSP00000370409
ENST00000290846 ENSP00000290846
ENST00000381019 ENSP00000370407
ENST00000441818 ENSP00000393014
ENST00000453630 ENSP00000398488
ENST00000456595 ENSP00000413880
ENST00000457572 ENSP00000407700
ENST00000476901
ENST00000486620
ENST00000465378
ENST00000496831
ENST00000485175
ENST00000493556
ENST00000463785
ENST00000479648
ENST00000491612
ENST00000485559
ENST00000470831
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
GO:0004810 tRNA adenylyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0016783 sulfurtransferase activity
Biological Process
GO:0006529 asparagine biosynthetic process
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022386
View Gene Order
ENSBTAG00000005595
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04122
Sulfur relay system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q2PPL5
UniProt Splice Variant
Entrez Gene 55687
UniGene Hs.439524 Hs.602392
RefSeq NM_001282782 NM_001282783 NM_001282784 NM_001282785 NM_018006 XM_005261678
HUGO HGNC:25481
OMIM 610230
CCDS CCDS14075 CCDS63510
HPRD 15571
IMGT
EMBL AL031588 DQ309998 DQ309999
GenPept ABC46690 ABC46691
RNA Seq Atlas 55687

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca