Homo sapiens Gene: SCG3
Summary
InnateDB Gene IDBG-12183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCG3
Gene Name secretogranin III
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104112
Encoded Proteins
secretogranin III
secretogranin III
secretogranin III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:51681353-51721031
Strand Forward strand
Band q21.2
Transcripts
ENST00000220478 ENSP00000220478
ENST00000542355 ENSP00000445205
ENST00000558709 ENSP00000452745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002576 platelet degranulation
GO:0007596 blood coagulation
GO:0030168 platelet activation
Cellular Component
GO:0005576 extracellular region
GO:0030658 transport vesicle membrane
GO:0034774 secretory granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8WXD2
TrEMBL H0YKC2
UniProt Splice Variant
Entrez Gene 29106
UniGene Hs.232618
RefSeq NM_001165257 NM_013243
HUGO HGNC:13707
OMIM 611796
CCDS CCDS10142 CCDS53947
HPRD
IMGT
EMBL AC020892 AF078851 AF453583 AK075314 AK290175 AK296466 AY359093 BC009511 BC014539 CH471082
GenPept AAD44483 AAH09511 AAH14539 AAL67431 AAQ89451 BAF82864 BAG52108 BAG59111 EAW77426
RNA Seq Atlas 29106