Version 5.4
Homo sapiens Protein: SCG3
Summary
InnateDB Protein IDBP-12185.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCG3
Protein Name secretogranin III
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000220478
InnateDB Gene IDBG-12183 (SCG3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions (By similarity). Neuroendocrine and endocrine secretory granules. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, heart, kidney, liver and skeletal muscle. {ECO:0000269PubMed:12098761}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002576 platelet degranulation
GO:0007596 blood coagulation
GO:0030168 platelet activation
Cellular Component
GO:0005576 extracellular region
GO:0030658 transport vesicle membrane
GO:0034774 secretory granule lumen
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXD2
PhosphoSite PhosphoSite-Q8WXD2
TrEMBL H0YKC2
UniProt Splice Variant
Entrez Gene 29106
UniGene Hs.232618
RefSeq NP_037375
HUGO HGNC:13707
OMIM 611796
CCDS CCDS10142
HPRD 11538
IMGT
EMBL AC020892 AF078851 AF453583 AK075314 AK290175 AK296466 AY359093 BC009511 BC014539 CH471082
GenPept AAD44483 AAH09511 AAH14539 AAL67431 AAQ89451 BAF82864 BAG52108 BAG59111 EAW77426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca