Homo sapiens Gene: LTBP2
Summary
InnateDB Gene IDBG-12199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTBP2
Gene Name latent transforming growth factor beta binding protein 2
Synonyms C14orf141; GLC3D; LTBP3; MSPKA; MSTP031; WMS3;
Species Homo sapiens
Ensembl Gene ENSG00000119681
Encoded Proteins
latent transforming growth factor beta binding protein 2
latent transforming growth factor beta binding protein 2
latent transforming growth factor beta binding protein 2
latent transforming growth factor beta binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:74498170-74612378
Strand Reverse strand
Band q24.3
Transcripts
ENST00000261978 ENSP00000261978
ENST00000553939 ENSP00000452110
ENST00000554861
ENST00000556690 ENSP00000451477
ENST00000556206 ENSP00000450668
ENST00000557425
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0019838 growth factor binding
Biological Process
GO:0006605 protein targeting
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009306 protein secretion
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q14767
TrEMBL G3V254 G3V3X5 G3V511
UniProt Splice Variant
Entrez Gene 4053
UniGene Hs.512776 Hs.597522
RefSeq NM_000428
HUGO HGNC:6715
OMIM 602091
CCDS CCDS9831
HPRD
IMGT
EMBL AC005479 AC013451 S82451 Z37976
GenPept AAB37459 AAF87081 CAA86030
RNA Seq Atlas 4053