Homo sapiens Gene: CCT5
Summary
InnateDB Gene IDBG-12328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCT5
Gene Name chaperonin containing TCP1, subunit 5 (epsilon)
Synonyms CCT-epsilon; CCTE; HEL-S-69; TCP-1-epsilon;
Species Homo sapiens
Ensembl Gene ENSG00000150753
Encoded Proteins
chaperonin containing TCP1, subunit 5 (epsilon)
chaperonin containing TCP1, subunit 5 (epsilon)
chaperonin containing TCP1, subunit 5 (epsilon)
chaperonin containing TCP1, subunit 5 (epsilon)
chaperonin containing TCP1, subunit 5 (epsilon)
chaperonin containing TCP1, subunit 5 (epsilon)
chaperonin containing TCP1, subunit 5 (epsilon)
chaperonin containing TCP1, subunit 5 (epsilon)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:10249921-10266412
Strand Forward strand
Band p15.2
Transcripts
ENST00000280326 ENSP00000280326
ENST00000423695
ENST00000503026 ENSP00000423318
ENST00000515390 ENSP00000426923
ENST00000511700 ENSP00000423087
ENST00000508451
ENST00000510326
ENST00000512975 ENSP00000425751
ENST00000503454 ENSP00000422744
ENST00000515676 ENSP00000427297
ENST00000506600 ENSP00000423052
ENST00000514674
ENST00000509846
ENST00000511995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 126 [view]
Protein-Protein 126 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031681 G-protein beta-subunit binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0009615 response to virus
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Formation of tubulin folding intermediates by CCT/TriC pathway
Protein folding pathway
Folding of actin by CCT/TriC pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1600
RefSeq NM_012073
HUGO
OMIM
CCDS CCDS3877
HPRD 06468
IMGT
EMBL
GenPept
RNA Seq Atlas