InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCL2L10

Summary

InnateDB Gene

IDBG-12400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L10

Gene Name

BCL2-like 10 (apoptosis facilitator)

Synonyms

BCL-B; Boo; Diva

Species

Homo sapiens

Ensembl Gene

ENSG00000137875

Encoded Proteins

IDBP-12402

BCL2-like 10 (apoptosis facilitator)

IDBP-587771

BCL2-like 10 (apoptosis facilitator)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:52109263-52112775

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000260442	ENSP00000260442
ENST00000561198	ENSP00000453562

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007283	spermatogenesis
GO:0007292	female gamete generation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Orthologs

No orthologs found for this gene

Cross-References

SwissProt

Q9HD36

TrEMBL

H0YMD5

UniProt Splice Variant

Entrez Gene

10017

UniGene

Hs.283672

RefSeq

NM_020396 XM_005254103

HUGO

HGNC:993

OMIM

606910

CCDS

CCDS10148

HPRD

IMGT

EMBL

AC023906 AF285092 AF326964 AJ458330 BC093826 BC093828 BC104442 BC104443

GenPept

AAG00503 AAH93826 AAH93828 AAI04443 AAI04444 AAK48715 CAD30221

RNA Seq Atlas

10017