Homo sapiens Gene: BCL2L10
Summary
InnateDB Gene IDBG-12400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL2L10
Gene Name BCL2-like 10 (apoptosis facilitator)
Synonyms BCL-B; Boo; Diva;
Species Homo sapiens
Ensembl Gene ENSG00000137875
Encoded Proteins
BCL2-like 10 (apoptosis facilitator)
BCL2-like 10 (apoptosis facilitator)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:52109263-52112775
Strand Reverse strand
Band q21.2
Transcripts
ENST00000260442 ENSP00000260442
ENST00000561198 ENSP00000453562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007283 spermatogenesis
GO:0007292 female gamete generation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9HD36
TrEMBL H0YMD5
UniProt Splice Variant
Entrez Gene 10017
UniGene Hs.283672
RefSeq NM_020396 XM_005254103
HUGO HGNC:993
OMIM 606910
CCDS CCDS10148
HPRD
IMGT
EMBL AC023906 AF285092 AF326964 AJ458330 BC093826 BC093828 BC104442 BC104443
GenPept AAG00503 AAH93826 AAH93828 AAI04443 AAI04444 AAK48715 CAD30221
RNA Seq Atlas 10017