Version 5.4
Homo sapiens Gene: IGHA1
Summary
InnateDB Gene IDBG-124374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGHA1
Gene Name immunoglobulin heavy constant alpha 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000211895
Encoded Proteins
IDBP-124376
immunoglobulin heavy constant alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type IG_C_gene
Genomic Location Chromosome 14:105707118-105708665
Strand Reverse strand
Band q32.33
Transcripts
ENST00000390547 ENSP00000374989
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0005515 protein binding
GO:0034987 immunoglobulin receptor binding
Biological Process
GO:0001895 retina homeostasis
GO:0003094 glomerular filtration
GO:0006955 immune response
GO:0018298 protein-chromophore linkage
GO:0019731 antibacterial humoral response
GO:0060267 positive regulation of respiratory burst
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0071748 monomeric IgA immunoglobulin complex
GO:0071751 secretory IgA immunoglobulin complex
GO:0071752 secretory dimeric IgA immunoglobulin complex
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.699841
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT IGHA1
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca