InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGHA1

Summary

InnateDB Protein

IDBP-124376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGHA1

Protein Name

immunoglobulin heavy constant alpha 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000374989

InnateDB Gene

IDBG-124374 (IGHA1)

Protein Structure

UniProt Annotation

Function

Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

Subcellular Localization

Disease Associations

Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005515	protein binding
GO:0034987	immunoglobulin receptor binding

Biological Process

GO:0001895	retina homeostasis
GO:0003094	glomerular filtration
GO:0006955	immune response
GO:0018298	protein-chromophore linkage
GO:0019731	antibacterial humoral response
GO:0060267	positive regulation of respiratory burst

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0071748	monomeric IgA immunoglobulin complex
GO:0071751	secretory IgA immunoglobulin complex
GO:0071752	secretory dimeric IgA immunoglobulin complex
GO:0072562	blood microparticle