Version 5.4
Homo sapiens Gene: HLA-E
Summary
InnateDB Gene IDBG-125081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-E
Gene Name major histocompatibility complex, class I, E
Synonyms EA1.2; EA2.1; HLA-6.2; MHC; QA1
Species Homo sapiens
Ensembl Gene ENSG00000204592
Encoded Proteins
IDBP-808177
major histocompatibility complex, class I, E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:30489406-30494205
Strand Forward strand
Band p22.1
Transcripts
ENST00000612468 ENSP00000480643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042605 peptide antigen binding
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042612 MHC class I protein complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04612
Antigen processing and presentation pathway
hsa04940
Type I diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05332
Graft-versus-host disease pathway
hsa04144
Endocytosis pathway
hsa05416
Viral myocarditis pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005516
HUGO
OMIM
CCDS CCDS34379
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca