Version 5.4
Homo sapiens Gene: DAP
Summary
InnateDB Gene IDBG-12509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAP
Gene Name death-associated protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112977
Encoded Proteins
IDBP-12513
death-associated protein
IDBP-362295
death-associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. [provided by RefSeq, Jul 2008]
This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:10679230-10761272
Strand Reverse strand
Band p15.2
Transcripts
ENST00000230895 ENSP00000230895
ENST00000432074 ENSP00000394163
ENST00000514882
ENST00000508253
ENST00000510546
ENST00000508646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0070513 death domain binding
Biological Process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010507 negative regulation of autophagy
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034198 cellular response to amino acid starvation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0097190 apoptotic signaling pathway
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039168
View Gene Order
ENSBTAG00000006346
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.75189
RefSeq NM_004394
HUGO
OMIM
CCDS CCDS3880
HPRD 02977
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca