Mus musculus Gene: Rock1
Summary
InnateDB Gene IDBG-128359.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rock1
Gene Name Rho-associated coiled-coil containing protein kinase 1
Synonyms 1110055K06Rik; Rock-I
Species Mus musculus
Ensembl Gene ENSMUSG00000024290
Encoded Proteins
Rho-associated coiled-coil containing protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067900:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:10064401-10181792
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000067947 ENSMUSP00000069549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0003383 apical constriction
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007159 leukocyte cell-cell adhesion
GO:0007165 signal transduction
GO:0007266 Rho protein signal transduction
GO:0016525 negative regulation of angiogenesis
GO:0022614 membrane to membrane docking
GO:0030036 actin cytoskeleton organization
GO:0032060 bleb assembly
GO:0032970 regulation of actin filament-based process
GO:0035556 intracellular signal transduction
GO:0043524 negative regulation of neuron apoptotic process
GO:0045616 regulation of keratinocyte differentiation
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051451 myoblast migration
GO:0051894 positive regulation of focal adhesion assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0001726 ruffle
GO:0005814 centriole
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030027 lamellipodium
GO:0032059 bleb
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Apoptosis pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Signaling by VEGF pathway
EPHA-mediated growth cone collapse pathway
Apoptotic cleavage of cellular proteins pathway
Sema4D induced cell migration and growth-cone collapse pathway
EPH-Ephrin signaling pathway
G alpha (12/13) signalling events pathway
EPHB-mediated forward signaling pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
Signal Transduction pathway
Apoptotic execution phase pathway
KEGG
Axon guidance pathway
TGF-beta signaling pathway pathway
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
REACTOME
G alpha (12/13) signalling events pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
Sema4D induced cell migration and growth-cone collapse pathway
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Axon guidance pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
EPHA-mediated growth cone collapse pathway
VEGFA-VEGFR2 Pathway pathway
EPH-Ephrin signaling pathway
KEGG
Regulation of actin cytoskeleton pathway
Pathogenic Escherichia coli infection pathway
TGF-beta signaling pathway pathway
Axon guidance pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Shigellosis pathway
INOH
PID NCI
EPHA forward signaling
Thromboxane A2 receptor signaling
Integrins in angiogenesis
EPHB forward signaling
Signaling events mediated by PRL
Signaling events mediated by VEGFR1 and VEGFR2
Noncanonical Wnt signaling pathway
Stabilization and expansion of the E-cadherin adherens junction
amb2 Integrin signaling
N-cadherin signaling events
Cross-References
SwissProt P70335
TrEMBL
UniProt Splice Variant
Entrez Gene 19877
UniGene Mm.410547 Mm.441225 Mm.471364 Mm.6710
RefSeq NM_009071 XM_006525725
OMIM
CCDS CCDS29053
HPRD
IMGT
MGI ID MGI:107927
MGI Symbol Rock1
EMBL AK050269 AK085974 BC057154 U58512
GenPept AAC53132 AAH57154 BAC34154 BAC39581
RNA Seq Atlas 19877