Mus musculus Gene: Net1
Summary
InnateDB Gene IDBG-128472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Net1
Gene Name neuroepithelial cell transforming gene 1
Synonyms mNET1; Net1a;
Species Mus musculus
Ensembl Gene ENSMUSG00000021215
Encoded Proteins
neuroepithelial cell transforming gene 1
neuroepithelial cell transforming gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173848:
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:3882565-3918220
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000091853 ENSMUSP00000089464
ENSMUST00000099946 ENSMUSP00000097529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0051451 myoblast migration
GO:0070301 cellular response to hydrogen peroxide
GO:0071479 cellular response to ionizing radiation
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
NRAGE signals death through JNK pathway
Signaling by Rho GTPases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Signalling by NGF pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of RhoA activity
Cross-References
SwissProt Q9Z206
TrEMBL Q3USZ7
UniProt Splice Variant
Entrez Gene 56349
UniGene Mm.22261
RefSeq NM_001047159 NM_019671
OMIM
CCDS CCDS26216 CCDS36583
HPRD
IMGT
MGI ID MGI:1927138
MGI Symbol Net1
EMBL AF094520 AJ010045 AK082128 AK088632 AK139921 BC004699
GenPept AAC71772 AAH04699 BAC38417 BAC40466 BAE24183 CAA08973
RNA Seq Atlas 56349