InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Net1

Summary

InnateDB Protein

IDBP-128474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Net1

Protein Name

neuroepithelial cell transforming gene 1

Synonyms

mNET1; Net1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089464

InnateDB Gene

IDBG-128472 (Net1)

Protein Structure

UniProt Annotation

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway. Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269PubMed:9670022}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11839749}. Nucleus {ECO:0000269PubMed:11839749}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017049	GTP-Rho binding

Biological Process

GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0051451	myoblast migration
GO:0070301	cellular response to hydrogen peroxide
GO:0071479	cellular response to ionizing radiation
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading